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Potential impact of a predictive test on the gene frequency of Huntington disease

✍ Scribed by Schoenfeld, Miriam ;Myers, Richard H. ;Berkman, Barbara ;Clark, Eleanor

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
446 KB
Volume
18
Category
Article
ISSN
0148-7299

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✦ Synopsis

Abstract

Fifty‐five individuals at 50% risk of inheriting Huntington disease (HD) were given in‐depth structured interviews to survey attitudes toward use of a predictive test and to assess the possible impact of such a test on the number of gene carriers born. Three‐quarters of the sample said they would take predictive test. Given a positive predictive or prenatal test, the number of individuals choosing to have children is reduced from 80% of the total sample to 42%, or by almost one‐half. The large proportion of at risk individuals who say they would use a predictive test underscores the importance of developing guidelines for its administration prior to implementation.

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