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Potential antitumor agents. 10. Synthesis and biochemical properties of 5-N-alkylamino-, N,N-dialkylamino-, and N-alkylacetamido-1-formylisoquinoline thiosemicarbazones

✍ Scribed by Mooney, Paul D.; Booth, Barbara A.; Moore, E. Colleen; Agrawal, Krishna C.; Sartorelli, Alan C.


Book ID
124071605
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
725 KB
Volume
17
Category
Article
ISSN
0022-2623

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✍ Ching-Hsin Kung; John N.D. Wurpel; Chul-Hoon Kwon πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 130 KB πŸ‘ 2 views

A series of (S)-(+)-5-n-propyl-2-iminohydantoins with various N-1 substituents were synthesized and tested for anticonvulsant activity to better understand the structure-activity relationship (SAR) of 2-iminohydantoins. Compounds with N-1 phenoxycarbonyl (2), ethoxycarbonyl (6), t-butoxycarbonyl (7)