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Potential aldose reductase inhibitors: 1,2,4-triazolidine-3,5-diones and 2-(3,4,5-trimethoxybenzoyl)-4,4-diethyl-3,5-isoxazolidinedione

✍ Scribed by I. H. Hall; R. A. Izydore; R. Simlot; O. T. Wong

Book ID
105401041
Publisher
Springer
Year
1992
Tongue
English
Weight
424 KB
Volume
48
Category
Article
ISSN
1420-682X

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Solid-phase synthesis of 1,2,4-triazolid
Solid-phase synthesis of 1,2,4-triazolidine-3,5-diones
✍ Kyung-Ho Park; Linda J Cox πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 56 KB

A traceless synthesis of 1,2,4-triazolidine-3,5-diones has been achieved through cyclo-elimination from solid-phase. This traceless cyclo-elimination release step is induced by catalytic amount of base or by simply refluxing the urea carbamate intermediate.