๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Potent, Selective, and Systemically-Available Inhibitors of Acyl-Coenzyme A:Cholesterol Acyl Transferase (ACAT)

โœ Scribed by McCarthy, Peter A.; Hamanaka, Ernest S.; Marzetta, Carol A.; Bamberger, Mark J.; Gaynor, B. J.; Chang, George; Kelly, Sarah E.; Inskeep, Philip B.; Mayne, James T.


Book ID
126782287
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
483 KB
Volume
37
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Inhibitors of acyl-CoA: Cholesterol O-ac
โœ Patrick M. O'Brien; Drago R. Sliskovic; Adele Bernabei; Timothy Hurley; Maureen ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 274 KB

The syntheses and biological activities for anilides derived from 2-phenyl-2-(dodecyl-2H-tetrazol-5-yl)acetic acid are described. Evidence is provided that one of these compounds, (+)-8b, stereoselectively inhibits ACAT in vitro and possesses superior efficacy in vivo compared to (-)-8b or the racem

Inhibitors of acyl-CoA: cholesterol O-ac
โœ D.R. Sliskovic; J.A. Picard; W.H. Roark; A.D. Essenburg; B.R. Krause; L.L. Minto ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 332 KB

The synthesis and structure-activity relationships of a series of malonester amide ACAT inhibitors are described. One of these compounds, 4s, was shown to be a potent inhibitor of both the intestinal and arterial enzymes, bioactive upon oral dosing (ex vivo bioassay) and efficacious in a clinically