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Potent, Selective Adenosine A1 Agonists as Potential Analgesics

โœ Scribed by P.J. Beswick; C. Bountra; N.M. Clayton; S.D. Collins; R.P.C. Cousins; C.D. Eldred; A. Naylor; M.J. Sheehan; D.J. Spalding


Book ID
105770685
Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
303 KB
Volume
13
Category
Article
ISSN
1054-2523

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5'-Ester derivatives of the potent adenosine agonists N6-[4-[[[[4-[[[(2-acetylaminoethyl)amino]carbonyl]methyl] anilino]carbonyl]methyl]phenyl]adenosine (N-AcADAC; 1) and N6-cyclopentyladenosine (CPA; 2) were prepared as prodrugs. Both alkyl esters or carbonates (designed to enter the brain by virtu