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N6-Cycloalkyladenosines. Potent, A1-selective adenosine agonists

โœ Scribed by Moos, Walter H.; Szotek, Deedee S.; Bruns, Robert F.


Book ID
125999702
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
253 KB
Volume
28
Category
Article
ISSN
0022-2623

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5'-Ester derivatives of the potent adenosine agonists N6-[4-[[[[4-[[[(2-acetylaminoethyl)amino]carbonyl]methyl] anilino]carbonyl]methyl]phenyl]adenosine (N-AcADAC; 1) and N6-cyclopentyladenosine (CPA; 2) were prepared as prodrugs. Both alkyl esters or carbonates (designed to enter the brain by virtu