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Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines

✍ Scribed by McNamara, Dennis J.; Berman, Ellen M.; Fry, David W.; Werbel, Leslie M.

Book ID
126281691
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
930 KB
Volume
33
Category
Article
ISSN
0022-2623

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πŸ“œ SIMILAR VOLUMES

The synthesis of novel nonclassical reve
The synthesis of novel nonclassical reversed bridge quinazoline antifolates as inhibitors of thymidylate synthase
✍ Aleem Gangjee; Mohit KotharΓ©; Roy L. Kisliuk πŸ“‚ Article πŸ“… 2000 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 427 KB

## Abstract 2‐Amino‐6‐methyl‐5‐(pyridin‐4‐ylsulfanyl)‐3__H__‐quinazolin‐4‐one (**3**, AG337) a lipophilic thymidylate synthase inhibitor, is currently in clinical trials as an antitumor agent. On the basis of the crystal structure of **3** and the classical inhibitor 10‐propargyl‐5,8‐dideazafolic a