Potent inhibition of human cytochrome P450 1 enzymes by dimethoxyphenylvinyl thiophene
โ Scribed by Sang-Kwang Lee; Yongmo Kim; Mie Young Kim; Sanghee Kim; Young-Jin Chun
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 584 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0253-6269
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Zafirlukast is a cysteinyl leukotriene antagonist used to treat allergic and exercise-induced asthma. This in vitro study used human liver microsomes to evaluate the inhibitory activity of zafirlukast versus six human cytochrome P450 (CYP) isoforms. Zafirlukast (0 -250 mM) was co-incubated with fixe
The metabolism of mirtazapine enantiomers was investigated in vitro using human lymphoblast microsomes transfected with human cDNA to overexpress either CYP1A2, CYP2C9, CYP2C19, CYP2D6 or CYP3A4 and assayed for mirtazapine enantiomers using a validated chiral method of high-performance liquid chroma
Human cytochrome P450 (P450) enzymes exhibit remarkable diversity in their substrate specificities, participating in oxidation reactions of a wide range of xenobiotic drugs. Previously, we reported that alpha-naphthoflavone (ANF) is bound to the recombinant P450 1A2 tightly and stabilizes an overall