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Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug–drug interactions

✍ Scribed by M. Katoh; M. Nakajima; N. Shimada; H. Yamazaki; T. Yokoi

Publisher
Springer
Year
2000
Tongue
English
Weight
265 KB
Volume
55
Category
Article
ISSN
0031-6970

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To establish a prediction system for drug-induced gynecomastia in clinical fields, a model reaction system was developed to explain numerically this side effect. The principle is based on the assumption that 50% inhibition concentration (IC 50 ) of drugs on the in vitro metabolism of estradiol (E2)