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Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions

✍ Scribed by Stanislav Micuda; Lucie Mundlova; Eva Anzenbacherova; Pavel Anzenbacher; Jaroslav Chladek; Leos Fuksa; Jirina Martinkova

Publisher
Springer
Year
2004
Tongue
English
Weight
241 KB
Volume
60
Category
Article
ISSN
0031-6970

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The interaction of antiparasitic drugs with the polymorphic cytochrome P450 2D6 was studied in human liver microsomes. Of ten different drugs tested, three quinolines, oxamniquine, primaquine and chloroquine inhibited microsomal CYP2D6-catalysed formation of l'hydroxybufuralol at concentrations tha