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Potent and Selective Non-Benzodioxole-Containing Endothelin-A Receptor Antagonists

โœ Scribed by Tasker, Andrew S.; Sorensen, Bryan K.; Jae, Hwan-Soo; Winn, Martin; von Geldern, Thomas W.; Dixon, Douglas B.; Chiou, William J.; Dayton, Brian D.; Calzadila, Samuel; Hernandez, Lisa; Marsh, Kennan C.; WuWong, J. Ruth; Opgenorth, Terry J.


Book ID
121078241
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
282 KB
Volume
40
Category
Article
ISSN
0022-2623

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ฮณ-Carbamate butenolide analogues as pote
โœ William C. Patt; Billy R. Reisdorph; Joseph T. Repine; Annette M. Doherty; Steph ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 272 KB

Continued SAR around our ET A selective series of butenolide antagonists, for example PD156707 (1) has yielded a new series of subnanomolar ET A selective antagonists. Depending upon solution pH, 1 exists as the ring closed butenolide form (shown) or as the tautomeric open chain keto-acid salt. Reac