Endothelin-1 is a potent vasoconstrictor that is thought to be involved in many human disease states. We have developed a series of indole non-peptide endothelin antagonists including PD 159110 (31), an ETA selective antagonist, and PD 159020 (37), a non-selective ETA/ETB antagonist. The discovery,
โฆ LIBER โฆ
1,3-Diarylindan-2-carboxylic Acids, Potent and Selective Non-Peptide Endothelin Receptor Antagonists
โ Scribed by Elliott, John D.; Lago, M. Amparo; Cousins, Russell D.; Gao, Aiming; Leber, Jack D.; Erhard, Karl F.; Nambi, Ponnal; Elshourbagy, Nabil A.; Kumar, Chandrika
- Book ID
- 120973270
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 572 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-2623
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Endothelin-1 is a potent vasoconstrictor which is thought to be involved in many human disease states. We have developed a series of indole non-peptide endothelin antagonists which display nanomolar receptor affinity. The representative compound from this series is PD 159433 ( 22), an ETA selective
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