Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei
✍ Scribed by Veronika Ehmke; Cornelia Heindl; Dr. Matthias Rottmann; Céline Freymond; Dr. W. Bernd Schweizer; Prof. Dr. Reto Brun; Dr. August Stich; Prof. Dr. Tanja Schirmeister; Prof. Dr. François Diederich
- Book ID
- 102804360
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 530 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1860-7179
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## Abstract PfENR A372M mutant showing a different conformation of Methionine compared to the Met206 of EcENR by Koustav Maity et al., pp 30–41.
## Abstract Enoyl acyl carrier protein reductase (ENR), which catalyzes the final and rate limiting step of fatty acid elongation, has been validated as a potential drug target. Triclosan is known to be an effective inhibitor for this enzyme. We mutated the substrate binding site residue Ala372 of