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Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei

✍ Scribed by Veronika Ehmke; Cornelia Heindl; Dr. Matthias Rottmann; Céline Freymond; Dr. W. Bernd Schweizer; Prof. Dr. Reto Brun; Dr. August Stich; Prof. Dr. Tanja Schirmeister; Prof. Dr. François Diederich


Book ID
102804360
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
530 KB
Volume
6
Category
Article
ISSN
1860-7179

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## Abstract Enoyl acyl carrier protein reductase (ENR), which catalyzes the final and rate limiting step of fatty acid elongation, has been validated as a potential drug target. Triclosan is known to be an effective inhibitor for this enzyme. We mutated the substrate binding site residue Ala372 of