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Effect of substrate binding loop mutations on the structure, kinetics, and inhibition of enoyl acyl carrier protein reductase from plasmodium falciparum

✍ Scribed by Koustav Maity; Tanushree Banerjee; Narayanappa Prabakaran; Namita Surolia; Avadhesha Surolia; Kaza Suguna

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 104 KB
Volume: 63
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.434

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✦ Synopsis

Abstract

PfENR A372M mutant showing a different conformation of Methionine compared to the Met206 of EcENR by Koustav Maity et al., pp 30–41.

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X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition

✍ Koustav Maity; Saligram Prabhakar Bhargav; Banumathi Sankaran; Namita Surolia; A 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 378 KB

## Abstract Triclosan, a well‐known inhibitor of Enoyl Acyl Carrier Protein Reductase (ENR) from several pathogenic organisms, is a promising lead compound to design effective drugs. We have solved the X‐ray crystal structures of __Plasmodium falciparum__ ENR in complex with triclosan variants havi