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Potency and selectivity of the tachykinin NK3 receptor antagonist SR 142801

✍ Scribed by Jean-Claude Beaujouan; Monique Saffroy; Yvette Torrens; Jacques Glowinski

Book ID
117098990
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
124 KB
Volume
319
Category
Article
ISSN
0014-2999

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A practical and scalable synthesis of SR
A practical and scalable synthesis of SR 142801, a tachykinin NK3 antagonist
✍ Huai.G. Chen; F.-Z. Chung; O.P. Goel; D. Johnson; S. Kesten; J. Knobelsdorf; H.T πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 230 KB

A practical and scalable total synthesis of tachykinin NK3 receptor antagonist SR 142801, The absolute configuration of the key intermediate 7 was determined by single crystal X-ray crystallography, on the basis of which, the absolute configuration of SR 142801 should be (R)-(+), instead of the rec