A practical and scalable synthesis of SR 142801, a tachykinin NK3 antagonist

✍ Scribed by Huai.G. Chen; F.-Z. Chung; O.P. Goel; D. Johnson; S. Kesten; J. Knobelsdorf; H.T. Lee; J.R. Rubin

• Book ID: 104364878
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 230 KB
• Volume: 7
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(97)00064-4

✦ Synopsis

A practical and scalable total synthesis of tachykinin NK3 receptor antagonist SR 142801,

The absolute configuration of the key intermediate 7 was determined by single crystal X-ray crystallography, on the basis of which, the absolute configuration of SR 142801 should be (R)-(+), instead of the recently reported (S)-(+). l