Postulated mode of action of lead on aminolevulinic acid dehydratase in chronic exposure
β Scribed by A. Trevisan; V. Chinello; A. Buzzo; G. P. Gori
- Publisher
- Springer-Verlag
- Year
- 1981
- Tongue
- English
- Weight
- 318 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0340-0131
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The first intermediate substrate in the heme synthetic pathway, 5-aminolevulinic acid (ALA), is neurotoxic in animal models and may be responsible for some of the adverse neurologic outcomes in lead poisoning and porphyria in adult humans. ALA is a substrate for the enzyme aminolevulinic acid dehydr
There are few data at present on the impact of lead (Pb) on amphibians, although declines in amphibian populations due to man-made changes in the environment have been recorded in recent years. The impact of Pb in adult frogs, Rana ridibunda, was therefore examined. Animals were exposed to 14 mg l(-