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Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP

✍ Scribed by Seaho Kim; Wei Huang; Emilio P. Mottillo; Anjum Sohail; Yoon-Ah Ham; M. Katie Conley-LaComb; Chong Jai Kim; Guri Tzivion; Hyeong-Reh Choi Kim; Shihua Wang; Yong Q. Chen; Rafael Fridman


Book ID
113486393
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
979 KB
Volume
1803
Category
Article
ISSN
0167-4889

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## Abstract Membrane‐type metalloproteinase‐1 (MT1‐MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro‐MMP‐2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP‐2 activation that yields to t