✦ LIBER ✦

Posttranslational modification as a means of anchoring acetylcholinesterase to the cell surface

✍ Scribed by Israel Silman; Anthony H. Futerman

Publisher: Wiley (John Wiley & Sons)
Year: 1987
Tongue: English
Weight: 908 KB
Volume: 26
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360260021

No coin nor oath required. For personal study only.

✦ Synopsis

Acetylcholinesterase (AChE) exists in multiple molecular forms that differ in their quaternary structure and mode of attachment to the cell surface. Attachment is achieved by posttranslational modification of the catalytic subunits. Two such modifications are described. One modification involves the attachment to subunit tetramers, via disulfide bridges, of a collagen-like fibrous anchor that serves to attach the enzyme, by ionic interactions, to the extracellular matrix. A second modification involves the covalent attachment of a single phosphatidylinositol residue, which serves to anchor the enzyme hydrophobically in the lipid bilayer of the plasma membrane. The detailed molecular structure, assembly, and modes of anchoring of these two classes of AChE are discussed.

📜 SIMILAR VOLUMES

Plasma surface modification of poly(D,L-

Plasma surface modification of poly(D,L-lactic acid) as a tool to enhance protein adsorption and the attachment of different cell types

✍ C. M. Alves; Y. Yang; D. Marton; D. L. Carnes; J. L. Ong; V. L. Sylvia; D. D. De 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB 👁 2 views

## Abstract We have studied the influence of oxygen radio frequency glow discharge (RfGD) on the surface and bulk properties of poly(D,L‐lactic acid) (PDLLA) and the effect of this surface modification on both protein adsorption and bone cell behavior. PDLLA films were characterized before and afte

The relationship of the cell surface to

The relationship of the cell surface to metabolism. II. The cell surface of yeast as the site of inhibition of glucose metabolism by uranium

✍ Rothstein, A. ;Larrabee, C. 📂 Article 📅 1948 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 559 KB

Affinity-mediated modification of electr

Affinity-mediated modification of electrical charge on a cell surface: A new approach to the affinity partitioning of biological particles

✍ Jesús Mendieta; Göte Johansson 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 621 KB

Polylysine has been covalently bound to human transferrin in a 1:1 molar ratio over a disulfide bond that can be easily split by reducing agents such as dithiothreitol. The association constant for the binding of the transferrin-polylysine derivative to transferrin receptors present on rat erythrobl

Display of lipase on the cell surface of

Display of lipase on the cell surface of Escherichia coli using OprF as an anchor and its application to enantioselective resolution in organic solvent

✍ Seung Hwan Lee; Jong-il Choi; Mee-Jung Han; Jong Hyun Choi; Sang Yup Lee 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 981 KB

ChemInform Abstract: N,N′-Disuccinimidyl

ChemInform Abstract: N,N′-Disuccinimidyl Carbonate as a Coupling Agent in the Synthesis of Thiophospholipids Used for Anchoring Biomembranes to Gold Surfaces.

✍ N. BODEN; R. J. BUSHBY; Q. LIU; S. D. EVANS; A. T. A. JENKINS; P. F. KNOWLES; R. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 2 views

Double pulsed field gradient (double-PFG

Double pulsed field gradient (double-PFG) MR imaging (MRI) as a means to measure the size of plant cells

✍ E. Özarslan; M. E. Komlosh; M. J. Lizak; F. Horkay; P. J. Basser 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 522 KB

Measurement of diffusion in porous materials and biological tissues with the pulsed field gradient (PFG) MR techniques has proven useful in characterizing the microstructure of such specimens noninvasively. A natural extension of the traditional PFG technique comprises multiple pairs of diffusion gr