Postsynthetic Modification of Peptides via Chemoselective N-Alkylation of Their Side Chains
✍ Scribed by Monfregola, Luca; Leone, Marilisa; Calce, Enrica; De Luca, Stefania
- Book ID
- 120049999
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 539 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1523-7060
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## Abstract Artificial amino acids carrying either the chromophore of the Green Fluorescent Protein (GFP) or a modification as their side chains have been synthesized: Boc‐protected alaninyl derivatives and Fmoc‐protected __N__‐(2‐aminoethyl)glycine‐functionalized amino acids were obtained and coul
## Abstract **The cover picture shows** a chromophore of the Green Fluorescent Protein, which undergoes fast internal conversion by rotation causing the quenching of its fluorescence in solution. In contrast, the intact protein shows a high fluorescence quantum yield and there is still a need to un