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Postsynthetic Modification of Oligonucleotides with Imidazophenazine Dye and its Effect on Duplex Stability

โœ Scribed by Dubey, Larysa; Ryazanova, Olga; Zozulya, Victor; Fedoryak, Dmytro; Dubey, Igor


Book ID
120969219
Publisher
Taylor and Francis Group
Year
2011
Tongue
English
Weight
338 KB
Volume
30
Category
Article
ISSN
0732-8311

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Five dimers containing amide linkages instead of the natural phosphodiester linkage were synthesized and incorporated into oligonucleotides. The length of the amide backbone was varied. The hybridization properties of the modified oligonucleotides with RNA complements and their conformational analys