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Effect of structural factors on the stability of duplexes formed by oligonucleotide conjugates with minor groove binders

✍ Scribed by V. A. Ryabinin; A. S. Butorin; K. Elen; A. Yu. Denisov; D. V. Pyshnyi; A. N. Sinyakov

Book ID: 106519294
Publisher: SP MAIK Nauka/Interperiodica
Year: 2005
Tongue: English
Weight: 90 KB
Volume: 31
Category: Article
ISSN: 1068-1620
DOI: 10.1007/s11171-005-0020-x

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Oligonucleotide — Minor Groove Binder 1:2 Conjugates: Side by Side Parallel Minor Groove Binder Motif in Stabilization of DNA Duplex

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Replacement of the phosphodiester linkag

Replacement of the phosphodiester linkage in oligonucleotides by an amide: Effect of backbone length on duplex stability with RNA complement

✍ Alain De Mesmaeker; Chantal Jouanno; Romain M. Wolf; Sebastian Wendeborn 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 322 KB

Five dimers containing amide linkages instead of the natural phosphodiester linkage were synthesized and incorporated into oligonucleotides. The length of the amide backbone was varied. The hybridization properties of the modified oligonucleotides with RNA complements and their conformational analys