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Postsynthetic DNA Modification through the Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction

✍ Scribed by Philipp M. E. Gramlich; Christian T. Wirges; Antonio Manetto; Thomas Carell

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
837 KB
Volume
47
Category
Article
ISSN
0044-8249

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## Abstract A series of 12‐ to 22‐membered macrocycles, with druglike functionality and properties, have been generated by using a simple and efficient copper‐catalyzed azide–acetylene cycloaddition reaction, conducted in flow in high‐temperature copper tubing, under environmentally friendly condit