Effect of temperature on triazole and bistriazole formation through copper-catalyzed alkyne–azide cycloaddition
✍ Scribed by Jaime González; Víctor M. Pérez; David O. Jiménez; Germán Lopez-Valdez; David Corona; Erick Cuevas-Yañez
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 921 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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## Abstract A series of 12‐ to 22‐membered macrocycles, with druglike functionality and properties, have been generated by using a simple and efficient copper‐catalyzed azide–acetylene cycloaddition reaction, conducted in flow in high‐temperature copper tubing, under environmentally friendly condit
## Abstract __N__‐substituted glycine oligomers, or peptoids, can be used in conjunction with the copper‐catalyzed [3 + 2] cycloaddition of azides and alkynes to generate branched polymer networks. By incorporating both azides and alkynes as side chain functionalities on the oligomer scaffolds, pep