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Postnatal Inorganic Lead Exposure Decreases the Number of Spontaneously Active Midbrain Dopamine Neurons in the Rat

โœ Scribed by M. Tavakoli-Nezhad; A.J. Barron; D.K. Pitts


Book ID
117329897
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
185 KB
Volume
22
Category
Article
ISSN
0161-813X

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## Abstract We investigated whether in utero exposure to the Gram(โˆ’) bacteriotoxin lipopolysaccharide (LPS) induces dopamine (DA) neuron loss in rats. The proinflammatory cytokine tumor necrosis factor ฮฑ (TNFโ€ฮฑ) kills DA neurons and is elevated in the brains of patients with Parkinson's disease (PD