𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Postmenopausal levels of sex hormones and risk of breast carcinoma in situ: Results of a prospective study

✍ Scribed by Anne Zeleniuch-Jacquotte; Yian Gu; Roy E. Shore; Karen L. Koenig; Alan A. Arslan; Ikuko Kato; Sabina Rinaldi; Rudolf Kaaks; Paolo Toniolo

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
75 KB
Volume
114
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We report on a prospective study to assess the association of postmenopausal serum levels of sex hormones with subsequent risk of breast carcinoma in situ. We conducted a case‐control study nested within the cohort of the New York University Women's Health Study, a large prospective study documenting a positive association of circulating levels of estrogens and androgens with invasive breast cancer. The study included 69 cases of incident in situ carcinoma and 134 individually matched controls. No statistically significant trend of increasing risk with increasing level of any of the hormones was observed. Odds ratios (95% CIs) for the highest tertile relative to the lowest were 1.10 (0.51–2.39) for estradiol, 0.95 (0.41–2.19) for estrone, 1.63 (0.69–3.88) for testosterone, 0.99 (0.44–2.24) for androstenedione, 0.99 (0.45–2.20) for dehydroepiandrosterone sulfate and 0.81 (0.38–1.74) for sex hormone–binding globulin. Adjusting for potential confounders did not materially affect the results, nor did limiting the analysis to the 59 cases of ductal carcinoma in situ, the lesion thought to be the direct precursor of most invasive breast cancers. Our results are at variance with the positive associations observed in this same cohort with risk of invasive breast cancer. Possible explanations for our results include lack of power, an effect of sex hormones limited to the progression from in situ to invasive tumors, overrepresentation of indolent tumors or an effect of sex hormones on the induction of only a subset of in situ tumors, those that would develop into invasive tumors. © 2004 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Circulating levels of sex steroid hormon
Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women
✍ Annekatrin Lukanova; Eva Lundin; Andrea Micheli; Alan Arslan; Pietro Ferrari; Sa 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 95 KB 👁 2 views

## Abstract Experimental and epidemiological data support a role for sex steroid hormones in the pathogenesis of endometrial cancer. The associations of pre‐diagnostic blood concentrations of estradiol, estrone, testosterone, androstenedione, DHEAS and SHBG with endometrial cancer risk were investi

Endogenous sex hormones and the risk of
Endogenous sex hormones and the risk of prostate cancer: A prospective study
✍ Jocelyn M. Weiss; Wen-Yi Huang; Sabina Rinaldi; Thomas R. Fears; Nilanjan Chatte 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 95 KB 👁 2 views

## Abstract Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has n

A prospective study of plasma prolactin
A prospective study of plasma prolactin levels and subsequent risk of breast cancer
✍ H. G. Kwa; F. Cleton; D. Y. Wang; R. D. Bulbrook; J. C. Bulstrode; J. L. Hayward 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 413 KB

## Abstract Plasma prolactin was measured in 2,572 premenopausal, 628 menopausal, and 1,666 peri‐ and postmenopausal women who were apparently healthy. Breast cancer was subsequently diagnosed in 47 of these women at a median time of 5 years after blood collection (pre‐cancer cases). Prolactin leve

Serum concentrations of estrogens, sex h
Serum concentrations of estrogens, sex hormone-binding globulin, and androgens and risk of breast cancer in postmenopausal women
✍ Laila Adly; Deirdre Hill; Mark E. Sherman; Susan R. Sturgeon; Thomas Fears; Caro 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 91 KB 👁 1 views

## Abstract We assessed the relationship between serum concentrations of estrogens, androgens, and sex hormone‐binding globulin and risk of breast cancer among postmenopausal women. Study participants provided serum prior to breast biopsy or mastectomy in 3 hospitals in Grand Rapids, Michigan betwe

A prospective study of adiposity and pos
A prospective study of adiposity and postmenopausal breast cancer risk: The Malmö diet and cancer study
✍ Petra H. Lahmann; Lauren Lissner; Bo Gullberg; Håkan Olsson; Göran Berglund 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 98 KB 👁 1 views

## Abstract High BMI is a well‐known risk factor for postmenopausal breast cancer. There have been some reports of excess risk in association with weight gain and WHR, but little is known about the influence of body fatness __per se.__ Using data from the Malmö Diet and Cancer Study, a prospective