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Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary

✍ Scribed by Thanasak Sueblinvong; Phadet Noophun; Kamol Pataradool; Nitaya Suwanwela; Kammant Phanthumchinda; Damrong Tresukosol

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 334 KB
Volume: 28
Category: Article
ISSN: 1341-8076
DOI: 10.1046/j.1341-8076.2002.00018.x

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✦ Synopsis

Abstract

A 31‐year‐old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic. The clinicoradiologic fea‐tures in this patient were consistent with posterior leukoencephalopathy, which is a rare complication of chemotherapy. Seizures were controlled by the anticonvulsive agent Dilantin (Pfizer, Khet Klongtoey, Bangkok) and she returned home without any permanent neurologic deficits. Follow‐up magnetic resonance imaging 2 weeks later showed complete resolution of the abnormalities. This syndrome has been previously reported following cisplatin‐based chemotherapy. Physicians should remain alert to the potential hazards of chemotherapy to the central nervous system. Risks and benefits should be seriously considered before starting treatment.

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