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Post-translational protein modifications in antigen recognition and autoimmunity

✍ Scribed by Hester A Doyle; Mark J Mamula

Book ID
117786967
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
84 KB
Volume
22
Category
Article
ISSN
1471-4906

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πŸ“œ SIMILAR VOLUMES

Post-translational modifications of self
Post-translational modifications of self antigens: implications for autoimmunity
✍ Stephen M Anderton πŸ“‚ Article πŸ“… 2004 πŸ› Elsevier Science 🌐 English βš– 123 KB

Alterations in amino acid sequence can generate neo-epitopes from self proteins, causing autoaggressive immune attack. There is a range of possible post-translational modifications (PTMs) of mammalian proteins that can allow immune recognition of neo-self epitopes. These effects can vary from overt