𝔖 Bobbio Scriptorium
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Post-translational modifications of lantibiotics

✍ Scribed by Thomas Kupke; Friedrich Götz

Publisher
Springer Netherlands
Year
1996
Tongue
English
Weight
1003 KB
Volume
69
Category
Article
ISSN
0003-6072

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✦ Synopsis

Several newly reported post-translational modification reactions are involved in lantibiotic biosynthesis. A short overview of the present knowledge on the post-translational modifications and on the enzymes involved in l antibiotic biosynthesis is given. The oxidative decarboxylation of the epidermin precursor peptide EpiA is described in detail. The b'MN-containing oxidoreductase EpiD is involved in the formation of the C-terminal S-[(Z)-2-aminovinyl]-Dcysteine residue of epidermin: under reducing conditions the side chain of the C-terminal cysteine residue of EpiA is converted to an enethiol. EpiD has no absolute substrate specificity and can be used for modification of peptides having the C-terminal consensus motif [VIIILI(M)/FIY/W]-[AISNITICI(IIL)]-C.

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