Post-translational modification of polyketide and nonribosomal peptide synthases

✍ Scribed by Christopher T Walsh; Amy M Gehring; Paul H Weinreb; Luis EN Quadri; Roger S Flugel

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 719 KB
• Volume: 1
• Category: Article
• ISSN: 1367-5931
• DOI: 10.1016/s1367-5931(97)80067-1

✦ Synopsis

The past year has witnessed a major advance in the study of polyketide and nonribosomal peptide biosynthesis with the identification of the phosphopantetheinyl transferase enzyme family, enzymes required to produce active, post-translationally modified polyketide and peptide synthases. Phosphopantetheinyl transferases required for fatty acid, peptide and siderophore biosynthesis have been characterized and a consensus sequence noted in order to facilitate future identification of additional proteins catalyzing phosphopantetheinyl transfer.