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Post-transfusion purpura: An enigma of alloimmunization

✍ Scribed by Peter Lau; Carol M. Sholtis; Richard H. Aster

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
365 KB
Volume
9
Category
Article
ISSN
0361-8609

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✦ Synopsis

Abstract

A patient with post‐transfusion purpura is reported. This female patient, sensitized by previous blood transfusion, developed symptomatic thrombocytopenia seven days after a second blood transfusion. A platelet antibody, which had anti‐P1 ^A1^ specificity, was identified by ^51^Cr‐release assay and by indirect immunofluorescence. Hemorrhage stopped abruptly after plasma exchange therapy. Thrombocytopenia did not recur when the patient was further challenged with P1^A1^‐positive blood and plasma. Anti‐P1^A1^ antibody, detectable by immunofluorescence but not by complement‐dependent platelet cytoxicity, persisted in high titer for at least one year after recovery. The heterogeneity and pathogenesis of this clinical syndrome are discussed.

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