Post-transfusion purpura associated with alloimmunization against the platelet-specific antigen, baka

✍ Scribed by Rudolph M. Keimowitz; Janice Collins; Kent Davis; Richard H. Aster

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 649 KB
• Volume: 21
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.2830210110

✦ Synopsis

Post-transfusion purpura (PTP) with severe thrombocytopenia occurred eight days after transfusion in a 28-year-old woman and responded to treatment with prednisone and plasma exchange. In contrast to nearly all previously studied cases of PTP, the patient's platelets were PlA1-positive and anti-Pl*' antibody could not be detected in serum obtained during the thrombocytopenic episode. Her serum was found to contain an antibody specific for a recently described platelet-specific alloantigen, Baka, in addition to multiple HLA-specific antibodies. The patient's platelets, typed following recovery, were Baka-negative. These findings indicate that post-transfusion purpura can occur in association with alloimmunization to platelet-specific antigens other than In performing the serologic studies, a close relationship and possible identity between Baka and another recently reported platelet antigen, Leks, was observed. A method for analyzing mixtures of cytotoxic platelet-reactive antibodies without separating the individual antibodies is described. P P .