Post-transcriptional inactivation of p53 in immortalized murine embryo fibroblast cells
β Scribed by Kim, Hyunggee; You, Seungkwon; Farris, James; Foster, Linda K; Foster, Douglas N
- Book ID
- 110064701
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 199 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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π SIMILAR VOLUMES
## Background The present study was carried out to determine whether the p53 pathway played a role in the spontaneous immortalization of the SC-2 chicken embryo fibroblast (CEF) cell line that has been in continuous culture for over three years. ## Results The SC-2 cell line emerged from an exten
## Abstract Some of the progeny of isolated mouse embryo fibroblasts acquire the ability to grow indefinitely during cultivation, presumably through some mutational events. The relevance of __p53__ mutations and loss of heterozygosity to the mechanism of such immortal growth capability remains cont
## Abstract Amphotropic murine leukemia virus (MLV) replicates in cells from various mammalian species including humans and is a potential contaminant in MLV vector preparations for human gene transfer studies. Because MLV replication proceeds through an RNA genome that is generated under the contr
## Abstract Oncogenic activation in primary murine fibroblasts initiates a senescenceβlike cell cycle arrest that depends on the p53 tumor suppressor pathway. Conditional p53 activation efficiently induced a reversible cell cycle arrest but was unable to induce features of senescence. In contrast,