Post-thymic tolerance to self antigens
β Scribed by Miller, Jacques F.A.P.
- Book ID
- 123248041
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 557 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0896-8411
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π SIMILAR VOLUMES
## Abstract Because of its role in positive selection, the ability of cortical epithelium to induce tolerance is controversial. On the one hand, experiments with transplanted thymuses showed that the recipients were functionally tolerant of all the antigens expressed by the cells of those thymuses,
The thymus expresses many genes previously thought to be specific for cell types in other organs. Thus, insulin genes are expressed in rare cells of the thymic medulla. Thymus transplantation demonstrates a functional capability of such expression for self-tolerance induction. Correlative studies su