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Post-menopausal hormonal therapy and gallbladder cancer risk

✍ Scribed by Silvano Gallus; Eva Negri; Liliane Chatenoud; Cristina Bosetti; Silvia Franceschi; Carlo La Vecchia

Publisher: John Wiley and Sons
Year: 2002
Tongue: French
Weight: 48 KB
Volume: 99
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.10411

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The relation between post‐menopausal hormone replacement therapy (HRT) and gallbladder cancer was analyzed in women above age 45 years, using data of a case‐control study conducted in Italy between 1985 and 1997, on 31 incident, histologically confirmed cases and 3,702 controls in hospital for acute, non‐neoplastic conditions. The multivariate odds ratio (OR) was 3.2 (95% confidence interval: 1.1–9.3) for those who had ever used HRT and the OR tended to rise with longer duration. Although based on small numbers, due to the rarity of the disease, these findings provide the first direct epidemiological evidence of an association between HRT and gallbladder cancer. © 2002 Wiley‐Liss, Inc.

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