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Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

✍ Scribed by Konstantinos K. Tsilidis; Naomi E. Allen; Timothy J. Key; Miguel A. SanJoaquin; Kjersti Bakken; Franco Berrino; Agnès Fournier; Eiliv Lund; Kim Overvad; Anja Olsen; Anne Tjønneland; Graham Byrnes; Veronique Chajes; Sabina Rinaldi; Marie-Christine Boutron-Ruault; Francoise Clavel-Chapelon; Jenny Chang-Claude; Rudolf Kaaks; Manuela Bergmann; Heiner Boeing; Yvoni Koumantaki; Domenico Palli; Valeria Pala; Salvatore Panico; Rosario Tumino; Paolo Vineis; H. Bas Bueno-de-Mesquita; Fränzel J.B. van Duijnhoven; Carla H. van Gils; Petra H.M. Peeters; Laudina Rodríguez; Carlos A. González; María-José Sánchez; Maria-Dolores Chirlaque; Aurelio Barricarte; Miren Dorronsoro; Kay-Tee Khaw; Sheila A. Rodwell; Teresa Norat; Dora Romaguera; Elio Riboli

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
303 KB
Volume
128
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by center and age, and adjusted for body mass index, smoking, diabetes, physical activity and alcohol consumption. Compared to never use of HT at study enrolment, current use of estrogen‐only (HR, 1.02; 95% CI, 0.79–1.31) or estrogen plus progestin (HR, 0.94; 95% CI, 0.77–1.14) was not significantly associated with the risk of colorectal cancer, and these associations did not vary by recency, duration, route of administration, regimen or specific constituent of HT. Our results show no significant association of estrogen‐only or estrogen plus progestin therapy with colorectal cancer risk.

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