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Possible target components for the inhibitory effect of N-ethylmaleimide on the activation of neutrophil NADPH oxidase

โœ Scribed by Jeen-Woo Park; Hee-Sae Park; Su Min Lee

Book ID
111742832
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
624 KB
Volume
45
Category
Article
ISSN
1521-6543

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The effects ofN-ethylmaleimide on extrac
The effects ofN-ethylmaleimide on extracellularly and intracellularly generated chemiluminescence in neutrophils indicate that the rate of deactivation of NADPH-oxidase is higher when the oxidase system is localized on the plasma membrane than when it is localized on the phagosomal membrane
โœ Dahlgren, Claes ;Sundqvist, Tommy ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons โš– 510 KB

Sustained generation of reactive oxygen metabolites following respiratory burst activation in neutrophils is a result of continued replenishment o f a pool of active NADPH-oxidase. The sulphydryl-modifying reagent N-ethylmaleimide (NEM) has been shown t o be without effect on the turnover of activat