✦ LIBER ✦

Possible mechanism for the effect of anorexic agents on feeding and hoarding behaviour in rats

✍ Scribed by John E. Blundell

Publisher: Springer
Year: 1971
Tongue: English
Weight: 273 KB
Volume: 22
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00401784

No coin nor oath required. For personal study only.

✦ Synopsis

Amphetamine, fenfiuramine, and chlorphentermine were tested for their effect on feeding and hoarding activity in rats, and the results interpreted according to a hypothalamic model for the regulation of motivated behaviour. All three compounds inhibited both feeding and hoarding, and the degree of inhibition was dose-dependent. Since feeding and hoarding are both influenced by activity in the lateral hypothalamus while feeding alone is modified by ventromedial hypothalamie activity, the result is consistent with a direct (inhibitory) action of the drugs on the lateral hypothalamus, rather than on the ventromedial region.

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