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Positron labeled muscarinic acetylcholine receptor antagonist: 2- and 4-[18F]fluorodexetimide. Syntheses and biodistribution

✍ Scribed by Hwang, Dah-Ren; Dence, Carmen S.; McKinnon, Zoe Ann; Mathias, Carla J.; Welch, Michael J.


Book ID
122675106
Publisher
Elsevier Science
Year
1991
Weight
661 KB
Volume
18
Category
Article
ISSN
0883-2897

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Tropapride, (exo)-2,3-dimethoxy-N-[8-(phenylmethyl)-8- azabicyclo[3.2.1]oct-3-yl]benzamide hydrochloride, has been labeled with fluorine-18 at the 2- and 4-positions of its benzylic group. Two synthetic pathways were investigated: the first one required the alkylation of the norbenzyl precursor with