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Synthesis and evaluation of 11C- and 18F-labeled 1-[2-(4-alkoxy-3-methoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazines as sigma receptor ligands for positron emission tomography studies

✍ Scribed by Kazunori Kawamura; Philip H Elsinga; Tadayuki Kobayashi; Shin-ichi Ishii; Wei-Fang Wang; Kiyoshi Matsuno; Willem Vaalburg; Kiichi Ishiwata


Book ID
117687920
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
323 KB
Volume
30
Category
Article
ISSN
0969-8051

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## Abstract 4‐[3‐[4‐(2‐Methoxyphenyl)piperazin‐1‐yl]propoxy]‐4‐aza‐tricyclo[5.2.1.02,6]dec‐8‐ene‐3,5‐dione (4), a potent and selective 5‐HT~1A~ agonist, was labeled by ^11^C‐methylation of the corresponding desmethyl analogue 3 with ^11^C‐methyl triflate. The precursor molecule 3 was synthesized fr