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Positron emission tomography demonstrates dopamine D2 receptor supersensitivity in the striatum of patients with early Parkinson's disease

✍ Scribed by Prof. U. K. Rinne; A. Laihinen; J. O. Rinne; K. Naågren; J. Bergman; U. Ruotsalainen

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
836 KB
Volume
5
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Striatal dopamine D~2~ receptor binding was studied in vivo with positron emission tomography in seven patients with early Parkinson's disease using [^11^C]–raclopride. The patients had unilateral symptoms and none of them had received levodopa treatment. The accumulation of [^11^C]–raclopride in the striatum was rapid and reached a steady state at approximately 40 min after injection. The binding of [^11^C]–raclopride was measured in the striatum and cerebellum: The total striatal radioactivity in both hemispheres was counted and the respective striatum/cerebellum ratios were calculated. The striatum/cerebellum ratio of [^11^C]–raclopride binding was significantly (p < 0.01) increased in the hemisphere contralateral to the parkinsonian symptoms as compared with the opposite hemisphere. Thus, this study demonstrates that there is denervation supersensitivity in dopamine D~2~ receptor binding in early Parkinson's disease.

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