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PET demonstrates different behaviour of striatal dopamine D-1 and D-2 receptors in early Parkinson's disease

✍ Scribed by Dr. J. O. Rinne; A. Laihinen; K. Någren; J. Bergman; O. Solin; M. Haaparanta; U. Ruotsalainen; U. K. Rinne

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
609 KB
Volume
27
Category
Article
ISSN
0360-4012

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✦ Synopsis

Striatal dopamine D-1 receptor binding was investigated in vivo with positron emission tomography (PET) in five patients with early Parkinson's disease using ["CI-SCH 23390. All patients had predominantly unilateral symptoms and showed a significant reduction in the accumulation of ["F]-6-F-DOPA in the striatum contralateral to the symptoms. None of the patients had received any antiparkinsonian medication. The striatal and cerebellar radioactivity was measured and corresponding striaturdcerebellum ratios were counted. The mean striaturdcerebellum ratio of ["CI-SCH 23390 binding was symmetric between the hemispheres. By contrast, the striaturn/ cerebellum ratio of [llC]raclopride binding, labelling dopamine D-2 receptors, was increased significantly in the hemisphere contralateral to the symptoms as compared with the opposite hemisphere. Thus, the present results show that the behaviour of striatal D-1 and D-2 receptors is different in early Parkinson's disease.

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