𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Positive effect of the hepatitis C virus nonstructural 5A protein on viral multiplication

✍ Scribed by D. Bonte; C. François; S. Castelain; C. Wychowski; J. Dubuisson; E. F. Meurs; G. Duverlie

Publisher
Springer Vienna
Year
2004
Tongue
English
Weight
354 KB
Volume
149
Category
Article
ISSN
1432-8798

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Apolipoprotein E interacts with hepatiti
Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles
✍ Wagane J. A. Benga; Sophie E. Krieger; Maria Dimitrova; Mirjam B. Zeisel; Marie 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 812 KB

Chronic hepatitis C virus (HCV) infection is a major cause of liver disease worldwide. Restriction of HCV infection to human hepatocytes suggests that liver-specific host factors play a role in the viral life cycle. Using a yeast-two-hybrid system, we identified apolipoprotein E (apoE) as a liver-de

Characterization of the effects of hepat
Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication
✍ Stephen J. Polyak; Denise M. Paschal; Susan McArdle; Michael J. Jr.; Darius Mora 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB 👁 1 views

The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. Biochemical studies have demonstrated that NS5A interacts in vitro with and inhibits the IFN-induced, RNAdependent protein kina

Mutations in the nonstructural region 5B
Mutations in the nonstructural region 5B of hepatitis C virus genotype 1b: Their relation to viral load, response to interferon, and the nonstructural region 5A
✍ Kazumasa Watanabe; Kentaro Yoshioka; Motoyoshi Yano; Masatoshi Ishigami; Koji Uk 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 2 views

## Abstract The nonstructural 5B (NS5B) protein of hepatitis C virus possesses RNA‐dependent RNA polymerase activity and plays an essential role in viral replication. The mutations in NS5B were determined and the correlation with viral load and response to interferon (IFN) were assessed. The entire

Association of amino acid substitution p
Association of amino acid substitution pattern in nonstructural protein 5A of hepatitis C virus genotype2a low viral load and response to interferon monotherapy
✍ Norio Akuta; Fumitaka Suzuki; Akihito Tsubota; Yoshiyuki Suzuki; Tetsuya Hosaka; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB 👁 2 views

## Abstract Patients with low titer (<0.5 mEq/ml) of hepatitis C virus (HCV) genotype 2a achieve high and sustained response (SR) rates to interferon (IFN) monotherapy, but we also encounter patients who are resistant to therapy. We explored the relationship between response to IFN and virological