Three novel monoclonal antibodies (MAbs) were established against a recombinant hepatitis C virus (HCV) core protein derived from cloned genotype 1 b HCV cDNA. MAbs C7-50 and C8-59 recognize a conserved linear epitope represented by amino acid residues 21 to 40 of the nucleocapsid protein. MAb C8-48
Characterization of monoclonal antibodies against the nonstructural 5A protein of hepatitis C virus
β Scribed by Sang Min Kang; Hyun-Jung Jun; Yun-Sook Lim; Soo-Ho Choi; Soon B. Hwang
- Publisher
- Springer Vienna
- Year
- 2009
- Tongue
- English
- Weight
- 399 KB
- Volume
- 154
- Category
- Article
- ISSN
- 1432-8798
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## Abstract The nonstructural proteins of hepatitis A virus (HAV), produced during active virus replication, are alternative antigens that could be used to differentiate disease from inactivated vaccineβinduced antibodies. An assay based on immune precipitation of proteins translated from transcrip
The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. Biochemical studies have demonstrated that NS5A interacts in vitro with and inhibits the IFN-induced, RNAdependent protein kina