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Positive and negative allosteric interactions on muscarinic receptors

✍ Scribed by Lucie Hejnová; Stanislav Tuček; Esam E. El-Fakahany


Book ID
113398910
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
383 KB
Volume
291
Category
Article
ISSN
0922-4106

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The classical (acetylcholine) binding sites of all five subtypes of muscarinic receptors are known to be subject to allosteric regulation by a variety of small molecules. The hallmarks of such modulation in binding assays are that the allosteric ligands can alter both the affinities and the rates of