Positional cloning of the HYP gene: A review
โ Scribed by Econs, Michael J
- Book ID
- 109884369
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 484 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0085-2538
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Positional cloning has attained prominence in the biomedical field through its ability to unravel the molecular basis of many elusive diseases, including cystic fibrosis, Huntington disease, and breast cancer. The strength of positional cloning is in its ability to identify a disease gene without pr
## BACKGROUND: The curly tail (ct) mutant mouse is one of the best-studied mouse models of spina bifida. The ct mutation has been localized to distal chromosome 4 in two independent studies and was recently postulated to be in the Grhl-3 gene. METHODS: A recombinant BALB/c-ct strain was generated