Position effect of cross-strand side-chain interactions on β-hairpin formation
✍ Scribed by Clara M. Santiveri; Manuel Rico; M. Angeles Jiménez
- Book ID
- 111753730
- Publisher
- Cold Spring Harbor Laboratory Press
- Year
- 2000
- Tongue
- English
- Weight
- 712 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0961-8368
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## Abstract The effects of N‐methylation and chain length on a cation–π interaction have been investigated within the context of a β‐hairpin peptide. Significant enhancement of the interaction and structural stabilization of the hairpin have been observed upon Lys methylation. Thermodynamic analysi
The effects on protein stability of negatively charged Glu side chains at different positions along the length of the a-helix were investigated in the two-stranded a-helical coiled-coil. A native coiled-coil has been designed which consists of two identical 35 residue polypeptide chains with a hepta