Stability of Cyclic β-Hairpins: Asymmetric Contributions from Side Chains of a Hydrogen-Bonded Cross-Strand Residue Pair

Side chain–backbone hydrogen bonding con

Side chain–backbone hydrogen bonding contributes to helix stability in peptides derived from an α-helical region of carboxypeptidase A

✍ Martha D. Bruch; Madan M. Dhingra; Dr. Lila M. Gierasch 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 823 KB

Recently, Presta and Rose proposed that a necessary condition for helix formation is the presence of residues at the N- and C-termini (called NTBs and CTBs) whose side chains can form hydrogen bonds with the initial four amides and the last four carbonyls of the helix, which otherwise lack intraheli