Porous β-tricalcium phosphate/collagen composites prepared in an alkaline condition

✍ Scribed by Chao Zou; Wenjian Weng; Kui Cheng; Piyi Du; Ge Shen; Gaorong Han; Binggang Guan; Weiqi Yan

• Book ID: 102294230
• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 449 KB
• Volume: 87A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.31686

✦ Synopsis

Abstract

Bone substitute materials with natural bone‐like structure are considered to be favorable for bone regeneration. In this work, porous β‐tricalcium phosphate (β‐TCP)/collagen composite consisting of bone‐like microstructural units was prepared using nanosized β‐TCP particles and alkaline‐disassembled collagen. The resulting composite showed a good interconnecting porous structure with ∼90% porosity and 100 ∼ 300 μm pore size. The pore walls were dense, and the combination status of collagen and nanosized β‐TCP particles demonstrated that nanosized β‐TCP particles tightly connected collagen microfibrils as a bone‐like microstructural unit. MTT and alkaline phosphatase (ALP) assays showed that the porous composite had enhanced effects on cellular proliferation and activity of osteoblast compared with a control of pure collagen. It is suggested that the adoption of nanosized β‐TCP particles is a main contribution to the formation of the composite with a bone‐like microstructural unit, and the unique microstructure could be a main role for the composite to have the positive influence on osteoblast cell proliferation. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008