✦ LIBER ✦

Porous Scaffolds Based on Cross-Linking of Poly(L-glutamic acid)

✍ Scribed by Bin Cao; Jingbo Yin; Shifeng Yan; Lei Cui; Xuesi Chen; Yongtao Xie

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 491 KB
Volume: 11
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.201000389

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Porous scaffolds based on water‐soluble PLGA and CS were prepared. The pores were verified to be alveolate, uniform and continuous. The effects of freezing temperature, freeze‐drying time, solid content and molecular weight of reactants on the pore structure of the scaffolds were studied. The scaffold morphology could be adjusted by changing the freezing temperature and solid content of reacting polymer. Their degradation rate can be adjusted by changing the proportion of PLGA and CS. The porosity of scaffolds was higher than 90% and the high swelling ratio showed that these scaffolds had excellent hydrophilic performance. The in vitro culture of chondrocytes indicates that the obtained PLGA/CS porous scaffolds are very promising biomaterials for tissue engineering applications. magnified image

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